Published in General, the 02/12/2018
A very useful visit to Francis Crick Institute to attend London Molecular Parasitology Club Meeting. The meeting was great opportunity to listen excellent speakers.
Published in General, the 09/10/2018
Kelly Lee has been successful in getting MRC PhD fellowship to work on NEK kinases in malaria. Many congratulations.
Published in Press Releases, the 31/08/2018
On World Mosquito Day, Edward Rea, a research fellow working on malaria parasite cell biology and development with Professor Rita Tewari, discusses why the fight against this mosquito-borne disease is far from over.
Published in Press Releases, the 05/07/2017
Science initiated in Nottingham has helped to form the foundation for the latest breakthrough in the global fight against malaria.
Researchers in the University of Nottingham’s School of Life Sciences were responsible for the identification of the molecular switches that control the three key stages of the malaria parasite’s life cycle – work which has underpinned a new discovery about the way in which the growth of the parasite is controlled.
Now, a team of international scientists led by Portuguese academics has discovered that one of the proteins identified by the Nottingham experts plays a vital role in modulating the parasite’s rate of replication by sensing the nutritional status of its host.
Published in General, the 26/05/2017
Our first Midlands Cell Cycle and Cytoskeleton Club meeting will take place on 11th July 2017.
This is not a open public event.
Published in General, the 01/04/2017
Anthonius Eze has been successful to get Commonwealth Academic Fellowship to work on Aurora kinases in malaria parasites. Many congratulations.
Published in Opportunities, the 20/03/2017
The UK has been a world leader in medical imaging since the 1960s, including the groundbreaking development of MRI led by Sir Peter Mansfield in Nottingham, enabling major advances in our knowledge about in vivo functional anatomy of whole organs and their substructures, especially the brain and as a non-invasive diagnostic tool.
Advanced imaging modalities have been crucial aids to our fundamental scientific understanding of cellular and molecular processes underlying biological function and disease. Research projects and training in this theme will demonstrate that advances in knowledge are not just a matter of having access to state-of-the-art technologies, but require an interdisciplinary combination of technological expertise and biological/medical knowledge to formulate answerable questions and to interpret the results.
Published in Opportunities, the 20/02/2017
Applications are invited from highly motivated and enthusiastic candidates for an MRC-funded PhD studentship aimed at identifying new therapeutic approaches to malaria.
Plasmodium, the causative agent of malaria, leads to 200 million cases and kills more than half a million people annually. Measures to control exposure to the mosquito vector have met with limited success and resistance to current drugs is emerging rapidly. This project will explore the roles of four NEK kinases expressed by the parasite and test their potential as novel therapeutic targets for malaria.
The objectives are to:
- define the subcellular localisation of NEKs during the parasite life cycle using advanced imaging techniques;
- use tagged NEK transgenic lines and mass spectrometry to identify interacting partners; and
- study the function of NEKs in parasite proliferation using conditional gene targeting in cell and animal models.
Published in General, the 20/12/2016
We got our work on Armadillo Protein published with groups from Geneva and Norway in Cell Host & Microbe on 14th Dec 2016 (: 10.1016/j.chom.2016.10.020).
Published in General, the 20/06/2016
Jessica Stock, our MRes student recieved a distinction for her thesis. She has now started a Phd position at the Research Institute of Molecular Pathology (Vienna, Austria).
Published in Opportunities, the 04/02/2016
Applications are invited from highly motivated, creative and committed candidate to the above role to investigate, and disseminate findings on a project funded by the BBSRC entitled Molecular and Cellular Dissection of Kinesin motor in Plasmodium in the group led by Professor Rita Tewari https://tewarilab.co.uk/.
Published in Press Releases, the 14/11/2015
The key to malaria's rampant growth has been explained by scientists. They say it is down to protein molecules called cyclins which cause cells to divide rapidly in the malaria parasite. The study, led by a team from the University of Nottingham, could lead to new treatments for malaria, the researchers said.
Published in Press Releases, the 13/11/2015
Scientists from The University of Nottingham have uncovered the role of cyclin - the protein molecule that drives the growth of malaria within mosquitoes.
The research, led by Professor Rita Tewari and Dr Bill Wickstead in the University’s School of Life Sciences and published in the scientific journal PLoS Pathogens (: 10.1371/journal.ppat.1005273 ), could pave the way to better understanding of how the malaria parasite thrives within its insect and human hosts and lead to potential new treatments.
Published in Press Releases, the 09/07/2014
Scientists searching for new drug and vaccine targets to stop transmission of one of the world’s deadliest diseases believe they are closer than ever to disrupting the life-cycle of this highly efficient parasite.
Dr Rita Tewari in the School of Life Sciences at The University of Nottingham has completed what she describes as a ‘Herculean study’ into the roles played by the 30 protein phosphatases and 72 kinases – enzymes that act as the ‘yin and yang’ switches for proteins – as the malaria parasite develops in the body and then in the mosquito gut.
Published in Press Releases, the 09/07/2014
Published in Press Releases, the 09/07/2014
Scientists searching for new drug and vaccine targets to stop transmission of one of the world's deadliest diseases believe they are closer than ever to disrupting the life cycle of this highly efficient parasite.
The findings come from research into the roles played by protein phosphatases - enzymes that act as 'on' and 'off' switches for proteins - as the malaria parasite develops in the body and then in the mosquito gut.
Published in Press Releases, the 10/03/2013
Scientists have discovered how a protein within the malaria parasite is essential to its survival as it develops inside a mosquito. They believe their findings identify this protein as a potential new target for drug treatments to prevent malaria being passed to humans.
Published in Press Releases, the 22/02/2013
Experts have disabled a unique member of the signalling proteins which are essential for the development of the malaria parasite.
They have produced a mutant lacking the ancient bacterial Shewanella-like protein phosphatase known as SHLP1 (pronounced 'shelph').
This mutant is unable to complete its complex life cycle and is arrested in its development in the mosquito. The discovery could help in the design of new drugs to arrest the spread of this killer disease.
The findings of their latest study are published on 21st February 2013, in the journal Cell Reports. (: 10.1016/j.celrep.2013.01.032 )
Published in Press Releases, the 20/09/2012
Scientists have discovered a unique enzyme that is a key player in enabling the malaria parasite to invade mosquitoes, raising hopes that the discovery could eventually lead to new strategies to prevent the spread of this deadly disease.
The work was a collaborative effort by scientists at the MRC's National Institute for Medical Research (NIMR; now part of the Francis Crick Institute) and colleagues from the Universities of Nottingham, Oxford, Edinburgh, Leicester and Imperial College London.
Published in Press Releases, the 26/03/2012
A consortium of chemists, structural biologists and parasitologists has discovered a series of N-myristoyl transferase inhibitors and identified the features necessary for their novel mode of binding to the enzyme. The work is published in the Journal of Medicinal Chemistry (: 10.1021/jm300040p).
Published in Press Releases, the 23/02/2012
Scientists have discovered a new target in their fight against the devastating global disease ‘malaria’ thanks to the discovery of a new protein involved in the parasite’s life cycle.
The research has uncovered a vital player in the sexual phase of the malaria parasite’s reproduction which could prove an effective target for new treatments to stop the disease in its tracks.
Published in Press Releases, the 20/10/2010
Scientists at The University of Nottingham and the Wellcome Trust Sanger Institute near Cambridge have pin-pointed the 72 molecular switches that control the three key stages in the life cycle of the malaria parasite and have discovered that over a third of these switches can be disrupted in some way.
Their research which has been funded by Wellcome Trust and the Medical Research Council (MRC) is a significant breakthrough in the search for cheap and effective vaccines and drugs to stop the transmission of a disease which kills up to a million children a year.
Until now little has been known about the cellular processes involved in the development of this deadly disease. The research, published in the journal Cell Host & Microbe (: 10.1016/j.chom.2010.09.006 ), involved the very first comprehensive functional analysis of protein kinases in any malaria parasite. It is also the largest gene knock-out study in Plasmodium berghei — a malaria parasite infecting rodents.