Publications

Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM. 2017. Nutrient sensing modulates malaria parasite virulence. Nature. 2017 Jul 5
: 10.1038/nature23009 | : 28678779

Alves E, Maluf FV, Bueno VB, Guido RV, Oliva G, Singh M, Scarpelli P, Costa F, Sartorello R, Catalani LH, Brady D, Tewari R, Garcia CR. 2016. Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2α) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum. Scientific Reports. 6:22093
: 10.1038/srep22093 | : 26915471 | Open Access

Wall RJ, Roques M, Katris NJ, Koreny L, Stanway RR, Brady D, Waller RF, Tewari R. 2016. SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector. Scientific Reports. 6:28604
: 10.1038/srep28604 | : 27339728 | Open Access

Jacot D, Tosetti N, Pires I, Stock J, Graindorge A, Hung YF, Han H, Tewari R, Kursula I, Soldati-Favre D. 2016. An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion. Cell Host & Microbe. 20(6):731-743
: 10.1016/j.chom.2016.10.020 | : 27978434

Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AA. 2016. The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain. The Journal of Biological Chemistry. 290:12147-12164
: 10.1074/jbc.M115.637694 | : 25802338 | Open Access

Safeukui I, Gomez ND, Adelani AA, Burte F, Afolabi NK, Akondy R, Velazquez P, Holder A, Tewari R, Buffet P, Brown BJ, Shokunbi WA, Olaleye D, Sodeinde O, Kazura J, Ahmed R, Mohandas N, Fernandez-Reyes D, Haldar K. 2015. Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen. MBio. 6(1)
: 10.1128/mBio.02493-14 | : 25604792 | Open Access

Andreadaki M, Mollenkopf HJ, Nika F, Brady D, Tewari R, Matuschewski K, Siden-Kiamos I. 2015. Global expression profiling reveals shared and distinct transcript signatures in arrested act2(-) and CDPK4(-) Plasmodium berghei gametocytes. Molecular and Biochemical Parasitology. 201(2):100-107
: 10.1016/j.molbiopara.2015.07.001 | : 26222913

Roques M, Wall RJ, Douglass AP, Ramaprasad A, Ferguson DJ, Kaindama ML, Brusini L, Joshi N, Rchiad Z, Brady D, Guttery DS, Wheatley SP, Yamano H, Holder AA, Pain A, Wickstead B, Tewari R. 2015. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes. PLoS Pathogens. 11(11):e1005273
: 10.1371/journal.ppat.1005273 | : 26565797 | Open Access

Guttery DS, Roques M, Holder AA, Tewari R. 2015. Commit and Transmit: Molecular Players in Plasmodium Sexual Development and Zygote Differentiation. Trends in Parasitology. 31(12):676-685
: 10.1016/j.pt.2015.08.002 | : 26440790

Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. 2014. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nature Chemistry. 6(2):112-121
: 10.1038/nchem.1830 | : 24451586

Tewari R, Patzewitz EM, Poulin B, Stewart L, Baker DA. 2014. Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target. PLoS One. 9(5):e96923
: 10.1371/journal.pone.0096923 | : 24805991 | Open Access

Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJ, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AM, Radhakrishnan A, Arold ST, Tate EW, Holder AA, Wickstead B, Pain A, Tewari R. 2014. Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell Host & Microbe. 16(1):128-140
: 10.1016/j.chom.2014.05.020 | : 25011111 | Open Access

Ferguson DJ, Balaban AE, Patzewitz EM, Wall RJ, Hopp CS, Poulin B, Mohmmed A, Malhotra P, Coppi A, Sinnis P, Tewari R. 2014. The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium. PLoS One. 9(12):e113923
: 10.1371/journal.pone.0113923 | : 25438048 | Open Access

Patzewitz EM, Guttery DS, Poulin B, Ramakrishnan C, Ferguson DJ, Wall RJ, Brady D, Holder AA, Szöőr B, Tewari R. 2013. An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission. Cell Reports. 3(3):622-629
: 10.1016/j.celrep.2013.01.032 | : 23434509 | Open Access

Guttery DS, Pittman JK, Frénal K, Poulin B, McFarlane LR, Slavic K, Wheatley SP, Soldati-Favre D, Krishna S, Tewari R, Staines HM. 2013. The Plasmodium berghei Ca2+/H+ exchanger, PbCAX, is essential for tolerance to environmental Ca2+ during sexual development. PLoS Pathogens. 9(2):e1003191
: 10.1371/journal.ppat.1003191 | : 23468629 | Open Access

Pulcini S, Staines HM, Pittman JK, Slavic K, Doerig C, Halbert J, Tewari R, Shah F, Avery MA, Haynes RK, Krishna S. 2013. Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes. The Journal of Infectious Diseases. 208(3):468-478
: 10.1093/infdis/jit171 | : 23599312 | Open Access

Knuepfer E, Suleyman O, Dluzewski AR, Straschil U, O'Keeffe AH, Ogun SA, Green JL, Grainger M, Tewari R, Holder AA. 2013. RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation. Cellular Microbiology. 16(5):657-672
: 10.1111/cmi.12181 | : 23937520 | Open Access

Poulin B, Patzewitz EM, Brady D, Silvie O, Wright MH, Ferguson DJ, Wall RJ, Whipple S, Guttery DS, Tate EW, Wickstead B, Holder AA, Tewari R. 2013. Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biology Open. 2(11):1160-1170
: 10.1242/bio.20136163 | : 24244852 | Open Access

Guttery DS, Holder AA, Tewari R. 2012. Sexual development in Plasmodium: lessons from functional analyses. PLoS Pathogens. 8(1):e1002404
: 10.1371/journal.ppat.1002404 | : 22275863 | Open Access

Guttery DS, Ferguson DJ, Poulin B, Xu Z, Straschil U, Klop O, Solyakov L, Sandrini SM, Brady D, Nieduszynski CA, Janse CJ, Holder AA, Tobin AB, Tewari R. 2012. A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathogens. 8(2):e1002554
: 10.1371/journal.ppat.1002554 | : 22383885 | Open Access

Das S, Basu H, Korde R, Tewari R, Sharma S. 2012. Arrest of nuclear division in Plasmodium through blockage of erythrocyte surface exposed ribosomal protein P2. PLoS Pathogens. 8(8):e1002858
: 10.1371/journal.ppat.1002858 | : 22912579 | Open Access

Guttery DS, Poulin B, Ferguson DJ, Szöőr B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM, Straschil U, Solyakov L, Green JL, Sinden RE, Tobin AB, Holder AA, Tewari R. 2012. A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion. PLoS Pathogens. 8(9):e1002948
: 10.1371/journal.ppat.1002948 | : 22912579 | Open Access

Slavic K, Delves MJ, Prudêncio M, Talman AM, Straschil U, Derbyshire ET, Xu Z, Sinden RE, Mota MM, Morin C, Tewari R, Krishna S, Staines HM. 2011. Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle. Antimicrobial Agents and Chemotherapy. 55(6):2824-2830
: 10.1128/AAC.01739-10 | : 21402842 | Open Access

Coppi A, Natarajan R, Pradel G, Bennett BL, James ER, Roggero MA, Corradin G, Persson C, Tewari R, Sinnis P. 2011. The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. The Journal of Experimental Medicine. 208(2):341-356
: 10.1084/jem.20101488 | : 21262960 | Open Access

Ogun SA, Tewari R, Otto TD, Howell SA, Knuepfer E, Cunningham DA, Xu Z, Pain A, Holder AA. 2011. Targeted disruption of py235ebp-1: invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein. PLoS Pathogens. 7(2):e1001288
: 10.1371/journal.ppat.1001288 | : 21379566 | Open Access

Gómez ND, Safeukui I, Adelani AA, Tewari R, Reddy JK, Rao S, Holder A, Buffet P, Mohandas N, Haldar K. 2011. Deletion of a malaria invasion gene reduces death and anemia, in model hosts. PLoS One. 6(9):e25477
: 10.1371/journal.pone.0025477 | : 21980474 | Open Access

Tewari R, Bailes E, Bunting KA, Coates JC. 2010. Armadillo-repeat protein functions: questions for little creatures. Trends in Cell Biology. 20(8):470-481
: 10.1016/j.tcb.2010.05.003 | : 20688255

Straschil U, Talman AM, Ferguson DJ, Bunting KA, Xu Z, Bailes E, Sinden RE, Holder AA, Smith EF, Coates JC, Tewari R. 2010. The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes. PLoS One. 5(9):e12901
: 10.1371/journal.pone.0012901 | : 20886115 | Open Access

Tewari R, Straschil U, Bateman A, Böhme U, Cherevach I, Gong P, Pain A, Billker O. 2010. The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission. Cell Host & Microbe. 8(4):377-387
: 10.1016/j.chom.2010.09.006 | : 20951971 | Open Access

Slavic K, Straschil U, Reininger L, Doerig C, Morin C, Tewari R, Krishna S. 2010. Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality. Molecular Microbiology. 75(6):1402-1413
: 10.1111/j.1365-2958.2010.07060.x | : 20132450 | Open Access

Mauduit M, Tewari R, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Snounou G, Rénia L, Grüner AC. 2010. Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites. Infection and Immunity. 78(5):2182-2188
: 10.1128/iai.01415-09 | : 20194600 | Open Access

Mauduit M, Grüner AC, Tewari R, Depinay N, Kayibanda M, Chavatte JM, Franetich JF, Crisanti A, Mazier D, Snounou G, Rénia L. 2009. A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites. PLoS One. 4(11):e7717
: 10.1371/journal.pone.0007717 | : 19890387 | Open Access

Reininger L, Tewari R, Fennell C, Holland Z, Goldring D, Ranford-Cartwright L, Billker O, Doerig C. 2009. An essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites. Journal of Biological Chemistry. 284(31):20858-20868
: 10.1074/jbc.M109.017988 | : 19491095 | Open Access

Ecker A, Bushell ES, Tewari R, Sinden RE. 2008. Reverse genetics screen identifies six proteins important for malaria development in the mosquito. Molecular Microbiology. 70(1):209-220
: 10.1111/j.1365-2958.2008.06407.x | : 18761621 | Open Access

Liu Y, Tewari R, Ning J, Blagborough AM, Garbom S, Pei J, Grishin NV, Steele RE, Sinden RE, Snell WJ, Billker O. 2008. The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes. Genes & Development. 22(8):1051-1068
: 10.1101/gad.1656508 | : 18367645 | Open Access

Grüner AC, Mauduit M, Tewari R, Romero JF, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Crisanti A, Sinnis P, Mazier D, Corradin G, Snounou G, Rénia L. 2007. Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS One. 2(12):e1371
: 10.1371/journal.pone.0001371 | : 18159254 | Open Access

Coppi A, Tewari R, Bishop JR, Bennett BL, Lawrence R, Esko JD, Billker O, Sinnis P. 2007. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host & Microbe. 2(5):316-327
: 10.1016/j.chom.2007.10.002 | : 18005753 | Open Access

Escaron CJ, Lees DM, Tewari R, Smith DF, Caron E. 2007. A simple, robust and versatile method to characterise intracellular parasitism. Molecular and Biochemical Parasitology. 153(1):72-76
: 10.1016/j.molbiopara.2007.01.008 | : 17303261

Raine JD, Ecker A, Mendoza J, Tewari R, Stanway RR, Sinden RE. 2007. Female inheritance of malarial lap genes is essential for mosquito transmission. PLoS Pathogens. 3(3):e30
: 10.1371/journal.ppat.0030030 | : 17335349 | Open Access

Tewari R, Dorin D, Moon R, Doerig C, Billker O. 2005. An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite. Molecular Microbiology. 58(5):1253-1263
: 10.1111/j.1365-2958.2005.04793.x | : 16313614 | Open Access

Tewari R, Ogun SA, Gunaratne RS, Crisanti A, Holder AA. 2005. Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo.. Blood. 105(1):394-396
: 10.1182/blood-2004-06-2106 | : 15339842 | Open Access

Tewari R, Rathore D, Crisanti A. 2005. Motility and infectivity of Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite protein. Cellular Microbiology. 7(5):699-707
: 10.1111/j.1462-5822.2005.00503.x | : 15839899 | Open Access

Reininger L, Billker O, Tewari R, Mukhopadhyay A, Fennell C, Dorin-Semblat D, Doerig C, Goldring D, Harmse L, Ranford-Cartwright L, Packer J, Doerig C. 2005. A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites. Journal of Biological Chemistry. 280(36):31957-31964
: 10.1074/jbc.M504523200 | : 15970588 | Open Access

Edvardsen RB, Lerat E, Maeland AD, Flåt M, Tewari R, Jensen MF, Lehrach H, Reinhardt R, Seo HC, Chourrout D. 2004. Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioica. Journal of Molecular Evolution. 59(4):448-457
: 10.1007/s00239-004-2636-5 | : 15638456

Billker O, Dechamps S, Tewari R, Wenig G, Franke-Fayard B, Brinkmann V. 2004. Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite. Cell. 117(4):503-514
: 10.1016/S0092-8674(04)00449-0 | : 15137943 | Open Access

Gillemans N, McMorrow T, Tewari R, Wai AW, Burgtorf C, Drabek D, Ventress N, Langeveld A, Higgs D, Tan-Un K, Grosveld F, Philipsen S. 2003. Functional and comparative analysis of globin loci in pufferfish and humans. Blood. 101(7):2842-2849
: 10.1182/blood-2002-09-2850 | : 12517812 | Open Access

Kropf P, Herath S, Tewari R, Syed N, Klemenz R, Müller I. 2002. Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. Infection and Immunity. 70(10):5512-5520
: 10.1128/IAI.70.10.5512-5520.2002 | : 12228277 | Open Access

Tewari R, Spaccapelo R, Bistoni F, Holder AA, Crisanti A. 2002. Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. Journal of Biological Chemistry. 277(49):47613-47618
: 10.1074/jbc.M208453200 | : 12244064 | Open Access

Gillemans N, Tewari R, Lindeboom F, Rottier R, de Wit T, Wijgerde M, Grosveld F, Philipsen S. 1998. Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the β-globin locus control region in vivo. Genes and Development. 12(18):2863-2873
: 10.1101/gad.12.18.2863 | : 9744863 | Open Access

Tewari R, Gillemans N, Wijgerde M, Nuez B, von Lindern M, Grosveld F, Philipsen S. 1998. Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the β-globin locus control region. EMBO Journal. 17(8):2334-2341
: 10.1093/emboj/17.8.2334 | : 9545245 | Open Access

Tewari R, Gillemans N, Harper A, Wijgerde M, Zafarana G, Drabek D, Grosveld F, Philipsen S. 1996. The human β-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene. Development. 122(12):3991-3999
Journal's Website: dev.biologists.org/content/122/12/3991 | : 9012519 | Open Access

Ellis J, Philipsen S, Strouboulis J, Pruzina S, Tewari R, Gillemans N, Drabek, D, Harper A, Grosveld F, Fraser P. 1995. The regulation of human β-globin gene expression; the roles of 5'HS1-4. Proceedings of the Ninth Conference on Hemoglobin Switching (held at Orcas Island, Washington, USA, 10-14 June 1994). 1:29-38

Nakayama I, Foresti F, Tewari R, Schartl M, Chourrout D. 1994. Sex chromosome polymorphism and heterogametic males revealed by two cloned DNA probes in the ZW/ZZ fish Leporinus elongatus. Chromosoma. 103(1):31-39
: 10.1007/BF00364723 | : 8013252

Tewari R, Michard-Vanhée C, Perrot E, Chourrout D. 1992. Mendelian transmission, structure and expression of transgenes following their injection into the cytoplasm of trout eggs. Transgenic Research. 1(6):250-260
: 10.1007/BF02525166

Tewari R, Rao SR. 1991. Replication status of the fragile X chromosome and its implications for reproductive performance in the Indian mole rat (Nesokia indica). Journal of Reproduction and Fertility. 91(1):203-206
: 10.1530/jrf.0.0910203 | : 1995848 | Open Access

Thelma BK, Tewari R, Juyal RC, Rao SR. 1991. Random/nonrandom X-chromosome inactivation in Nesokia indica: possible influence of heterochromatin. Cytogenetics and Cell Genetics. 56(2):87-90
: 10.1159/000133056 | : 2013237

Tewari R, Juyal RC, Rao SR. 1989. Significance of fragile sites on the sex chromosome of Nesokia indica. Nucleus. 32:93-102

Thelma BK, Juyal RC, Tewari R, Rao SR. 1988. Does heterochromatin variation potentiate speciation? A study in Nesokia. Cytogenetics and Cell Genetics. 47(4):204-208
: 10.1159/000132550 | : 3416654

Tewari R, Juyal RC, Thelma BK, Das BC, Rao SR. 1987. Folate-sensitive fragile sites on the X-chromosome heterochromatin of the Indian mole rat, Nesokia indica. Cytogenetics and Cell Genetics. 44(1):11-17
: 10.1159/000132334 | : 3816302

Simon MM, Ali S, Tewari R, Simon HG, Müller-Hermelink HK, Epplen JT. 1986. Leukemic cells arise from cloned cytotoxic lymphocytes during cell culture. European Journal of Immunology. 16(10):1269-1276
: 10.1002/eji.1830161014 | : 3095125

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